Denis Rousseau

Date du document : 12 décembre 2013
Dernière mise à jour le : 18 février 2014

Education / Graduation / Career

  • 1989 - UJF - Master of Biology
  • 1992 - UJF - PhD in Molecular and Cellular Biology
  • 1993-1997 - McGill University and Institut de Biologie Structurale - Post-Doctoral Position

Teaching: The main disciplines

  • Molecular and Cellular Biology and Genetic
  • Virology
  • Experimental cancerology

Research Topics

  • Metabolism disease
  • Fundamental research on mitochondria (ATAD3)
  • Experimental cancerology


  • Denis ROUSSEAU, Roger KASPAR, Igor ROSENWALD, Lee GEHRKE and Nahum SONENBERG (1996) Proceedings of National Academy of Sciences USA 93, 1065-1070. Overexpression of Cyclin D1 and Ornithine decarboxylase in cells overexpressing eIF-4E is mediated by increased nucleo-cytoplasmic transport of their mRNAs. IF=10,9 - TC=271.
  • Denis ROUSSEAU, Anne-Claude GINGRAS, Arnim PAUSE and Nahum SONENBERG (1996) Oncogene 13, 2415-2420. The eIF-4E Binding Proteins 1 and 2 are negative regulators of cell growth. IF=6,7 -TC=162.
  • Denis ROUSSEAU, Dominique CANELLA, Jérôme BOULAIRE, Patrick FITZGERALD, Arun FOTEDAR and Rati FOTEDAR (1999) Oncogene 18, 3290-3302. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway. IF=6,7 - TC=88.
  • Marc DUBOURDEAU, Tatsuo MIYAMURA, Yoshiharu Matsuura, Laurent ALRIC, Bernard PIPY and Denis ROUSSEAU (2002) Journal of Hepatology 37, 486-492. Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21WAF1 down-regulation - effect of transforming growth factor ß. IF=5 - TC=17.
  • Daniel F. BOGENHAGEN, Denis ROUSSEAU and Stéphanie BURKE (2008) Journal of Biological Chemistry 283, 3665-3675. The layered structure of human mtDNA nucleoids. IF=5,6 – TC=135.
  • Arnaud HUBSTENBERGER, Gérard LABOURDETTE, Jacques BAUDIER and Denis ROUSSEAU (2008) Experimental Cell Research 314, 2870-2883. ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties. IF=3,8 – TC=16.
  • Benoît GILQUIN, Brian R. CANNON, Arnaud HUBSTENBERGER, Boualem MOULOUEL, Elin FALK, Nicolas MERLE, Nicole ASSARD, Sylvie KIEFFER, Denis ROUSSEAU,  Paul T. WILDER, David J. WEBER, and Jacques BAUDIER (2010) Molecular and Cellular Biology 30, 2724-36. The calcium-dependent interaction between S100B and the mitochondrial AAA-ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A. IF=7,1 - TC= 7.
  • Shuijie LI, Fredérique LAMARCHE, Romain CHARTON, Christian DELPHIN, Olivier GIRES, Arnaud HUBSTENBERGER, Uwe SCHLATTNER and Denis ROUSSEAU (2013) Expression analysis of ATAD3 isoforms in rodent and humancell lines and tissues. Under Publication at Gene. IF=2,2.
  • Shuijie LI, Benjamin CLEMENCON, Patrice CATTY, Gérard BRANDOLIN, Uwe SCHLATTNER and Denis ROUSSEAU (2012). Protein Expression and Purification 83, 211–216. Human ATAD3A expression and purification in Saccharomyces cerevisiae IF=1,93.
  • Shuijie LI, Yiao YIAO, Rui Xu, Cécile COTTET, Uwe SCHLATTNER, Kan LIAO and Denis ROUSSEAU (2013) ATAD3A is a limiting factor in mitochondrial fragmentation and lipid storage during 3T3-L1 adipogenesis. Under submission at MCB. IF=5,4.

Interests, Projects, Ideas

Je travaille depuis 2003 sur une ATPase mitochondriale, ATAD3, impliquée dans le métabolisme énergétique et le cycle cellulaire ainsi que dans des pathologies métaboliques et le cancer.

External links